A TISSUE-ENGINEERED JELLYFISH WITH BIOMIMETIC PROPULSION PDF

Shakam Any view or opinion expressed in any Material is the view or opinion of the person who posts such view or opinion. SheehyKevin Kit Parker Biomaterials I would like to receive updates when further comments, recommendations, or dissenting opinions are publishing on this article. Accordingly you may only post Material that you have the right to do so. A summary of the content will be automatically included. EvansMolly M Stevens Nature materials Modeling of cardiac muscle thin films: The process of evolution missed a lot of good solutions. CiteSeerX — A tissue-engineered jellyfish with biomimetic propulsion The protein pattern serves itssue-engineered a road map for growth and organization of dissociated rat tissue—individual heart muscle cells that retain the ability to contract—into a coherent swimming muscle.

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Recent advances in the mechanistic understanding of biosynthetic compound materials 1 — 3 , computer-aided design approaches in molecular synthetic biology 4 , 5 and traditional soft robotics 6 , 7 , and increasing aptitude in generating structural and chemical microenvironments that promote cellular self-organization 8 — 10 have enhanced the ability to recapitulate such hierarchical architecture in engineered biological systems.

Here we combined these capabilities in a systematic design strategy to reverse engineer a muscular pump. We report the construction of a freely swimming jellyfish from chemically dissociated rat tissue and silicone polymer as a proof of concept.

The combination of the engineering design algorithm with quantitative benchmarks of physiological performance suggests that our strategy is broadly applicable to reverse engineering of muscular organs or simple life forms that pump to survive. Jellyfish represent a unique test case for design-based tissue engineering of a functional device Supplementary Fig.

Jellyfish medusae feature a radially symmetric, transparent body powered by a few, readily identifiable cell types, such as motor neurons and striated muscle 11 , 12 , and they generate quantifiable output functions, for example, well-defined feeding and swimming currents 13 , 14 , based on straightforward body-fluid interactions 15 , We started by identifying the key factors contributing to the jellyfish stroke cycle and its functions, that is, feeding and propulsion Fig.

First, previous studies and observations 17 , 18 have highlighted the importance of symmetric and complete bell contraction, which the jellyfish achieves by synchronously activating its axisymmetric musculature through a system of distributed pacemakers, resulting in controlled folding of the lobed or otherwise compressible bell Fig.

We reasoned that a sheet of cultured muscle tissue synchronized by an electrical field would be functionally equivalent Fig. For the engineered construct, we envisioned that a bilayer of muscle and synthetic elastomer would be suitable to mimic this interaction, that is, the muscle would provide the force to contract the bell, and the elastomer would act to restore the original shape Fig.

Third, previous research has highlighted the contribution of viscous, fluid boundary layers to efficient solid-fluid interactions in juvenile medusae and other aquatic organisms Fig. We concluded that the geometry of our construct should be chosen based on ambient fluid conditions so as to facilitate the formation of boundary layers that fill the gaps between neighboring lobes Fig.

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Publication: A tissue-engineered jellyfish with biomimetic propulsion

Recent advances in the mechanistic understanding of biosynthetic compound materials 1 — 3 , computer-aided design approaches in molecular synthetic biology 4 , 5 and traditional soft robotics 6 , 7 , and increasing aptitude in generating structural and chemical microenvironments that promote cellular self-organization 8 — 10 have enhanced the ability to recapitulate such hierarchical architecture in engineered biological systems. Here we combined these capabilities in a systematic design strategy to reverse engineer a muscular pump. We report the construction of a freely swimming jellyfish from chemically dissociated rat tissue and silicone polymer as a proof of concept. The combination of the engineering design algorithm with quantitative benchmarks of physiological performance suggests that our strategy is broadly applicable to reverse engineering of muscular organs or simple life forms that pump to survive. Jellyfish represent a unique test case for design-based tissue engineering of a functional device Supplementary Fig. Jellyfish medusae feature a radially symmetric, transparent body powered by a few, readily identifiable cell types, such as motor neurons and striated muscle 11 , 12 , and they generate quantifiable output functions, for example, well-defined feeding and swimming currents 13 , 14 , based on straightforward body-fluid interactions 15 , We started by identifying the key factors contributing to the jellyfish stroke cycle and its functions, that is, feeding and propulsion Fig.

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A tissue-engineered jellyfish with biomimetic propulsion

Nat Biotechnol. A tissue-engineered jellyfish with biomimetic propulsion. Reverse engineering of biological form and function requires hierarchical design over several orders of space and time. Recent advances in the mechanistic understanding of biosynthetic compound materials, computer-aided design approaches in molecular synthetic biology 4,5 and traditional soft robotics, and increasing aptitude in generating structural and chemical micro environments that promote cellular self-organization have enhanced the ability to recapitulate such hierarchical architecture in engineered biological systems. Here we combined these capabilities in a systematic design strategy to reverse engineer a muscular pump.

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A tissue-engineered jellyfish with biomimetic propulsion.

Tojar A tissue-engineered jellyfish with biomimetic propulsion. Disclosures Policy Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality. The similarities help reveal tussue-engineered you need to do to design a bio-inspired pump. Link to publication in Scopus.

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