PSYCHOPHARMACOLOGIE ESSENTIELLE PDF

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This article has been cited by other articles in PMC. Introduction Combinations of psychoactive treatments are frequently used to treat impulsivity, aggressiveness, or anxiety in patients with resistant schizophrenia.

The prevalence of psychotic disorders in epileptic patients is significantly higher compared with the general population [ Clancy et al. Clozapine CLZ; 8-chloro 4-methylpiperazinyl -5H-dibenzo[b,e][1,4]-diazepine is an atypical antipsychotic indicated for resistant schizophrenia or in cases of intolerance to the other antipsychotic agents. CLZ has a complex pharmacological profile because of its binding properties.

CLZ is recommended as third-line treatment because of the side effects in The coadministration of treatments may induce the modulation of the pharmacokinetics of CLZ via the enzyme inhibition or induction of cytochrome P CYP This led to an evaluation of the factors of variability in plasma concentration of CLZ and its active metabolites. Plasma levels are also indicative of the quality of compliance.

This is a choice anti-epileptic treatment, anti-impulsive and mood stabilizer as with CBZ [ Stahl, ]. OXC is indicated in the treatment of partial seizures with or without secondary generalization. After absorption, an important proportion of OXC undergoes rapid reduction in a pharmacologically active metabolite, monohydroxy derivative MHD; 10, dihydrohydroxy-5H-dibenzo[f,b]azepinecarboxamide or licarbazepine while a minority of MHD is oxidized in pharmacologically inactive dihydroxy derivative DHD; carbamazepine,dihydro,dihydroxy [ Flesch, ].

Case report We report the case of a year-old White male inpatient with schizophrenia associated with antisocial personality and hospitalization for 5 years after serious aggressive behavior. The patient reported having a personal history of addiction to cannabis, weaned for 9 years.

Each of these treatments were prescribed for more than 1 year. During hospitalization, the patient presented with a seizure characterized by lower limb clonus followed by falls, deviations of gaze and consciousness disorder. Partial improvement in neurologic symptoms has been observed persistence of only slight clonus associated with an increase of dissociative symptoms such as listening attitudes and thoughts disorders. These symptoms were consistent with those usually observed in this patient during psychotic exacerbation.

Weekly and biweekly blood samples were drawn by a nurse in the psychiatric unit in which the patient was hospitalized. They were collected in two tubes without gel or preservative agent at 12 h post-dose in the morning at 8 am for a treatment taken at 8 pm.

CLZ doses were administrated in the presence of the nurse who verified the adherence each time.

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Psychopharmacologie Essentielle Pdf

This article has been cited by other articles in PMC. Introduction Combinations of psychoactive treatments are frequently used to treat impulsivity, aggressiveness, or anxiety in patients with resistant schizophrenia. The prevalence of psychotic disorders in epileptic patients is significantly higher compared with the general population [ Clancy et al. Clozapine CLZ; 8-chloro 4-methylpiperazinyl -5H-dibenzo[b,e][1,4]-diazepine is an atypical antipsychotic indicated for resistant schizophrenia or in cases of intolerance to the other antipsychotic agents. CLZ has a complex pharmacological profile because of its binding properties. CLZ is recommended as third-line treatment because of the side effects in The coadministration of treatments may induce the modulation of the pharmacokinetics of CLZ via the enzyme inhibition or induction of cytochrome P CYP

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